This page tracks new and upcoming treatment options for endometriosis. What’s in development? What’s promising? What’s available soon? Current topics include MT-2990, FOR-6219, INT-777, TAK-385, clotrimazole, ginsenoside, SHR7280, gene therapy, Elagolix, and more. Jump to section: News, Research, Clinical Trials
Last updated: 4 years ago
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News
- Experts believe it’s time for a radical rethink of how endometriosis is treated Oct 5, 2020
- New Rat Model of Endometriosis Could Help Researchers Develop New Treatments for the Condition Sep 3, 2020
- How Common Treatments For Endometriosis Are Failing Those With Chronic Pain Aug 3, 2020
- U.S. House Approves Doubling Funding for Endometriosis Research to $26 Million Annually Jul 31, 2020
- Endometriosis Research Provides New Origin Clues, Potential Diagnostic and Possible Treatment Avenues Jul 22, 2020
- Nanomedicine offers hope in battling endometriosis Jun 22, 2020
- NIH-funded study links endometriosis to DNA changes Jun 19, 2020
- Epigenetic Changes in Reproductive Cells Could Help Diagnose Endometriosis Jun 18, 2020
- Relugolix Combination Therapy May Be The Way To Cope With Endometriosis Symptoms Apr 26, 2020
- ObsEva Announces Publication of Abstracts from Phase 2b EDELWEISS Trial of Linzagolix in Endometriosis Apr 22, 2020
- Myovant’s Endometriosis Treatment Hits the Mark in First of Two Phase III Trials Apr 22, 2020
- Myovant Sciences Announces Positive Results from Phase 3 Study Evaluating Once-Daily Relugolix Combination Therapy in Women with Endometriosis and from Ovulation Inhibition Study Apr 22, 2020
- Researchers use nanotechnology to develop new treatment for endometriosis Apr 6, 2020
- Summary: Accurate diagnosis of endometriosis using serum microRNAs Mar 17, 2020
- Endometriosis diagnosis taking years as women given outdated advice when seeking treatment Mar 6, 2020
- Women with endometriosis ‘finally being believed’ Mar 3, 2020
- MPs Have Launched An Enquiry Into Endometriosis To Improve Diagnosis, Treatment And Support Feb 11, 2020
- Infographic: How Can We Find an Effective Endometriosis Treatment? Feb 5, 2020
- Cannabinoids improve symptoms in mice with endometriosis Jan 14, 2020
- Tiny Fibers Carrying Curcumin May Be Targeted Endometriosis Treatment, Study Suggests Jan 2, 2020
- Early research points to possible new endometriosis treatment Dec 3, 2019
- Endometriosis could be treated with cancer drug, study suggests Dec 2, 2019
- Too many patients with endometriosis are being prescribed opioids and not enough people are aware. Not even physicians. Nov 19, 2019
- Australian women turning to cannabis to treat endometriosis symptoms Nov 11, 2019
- Research Has Ignored Endometriosis For Decades, And It’s Now Costing All of Us Oct 13, 2019
- Forendo Pharma commences Phase 1b Proof of Mechanism study with its lead endometriosis program, HSD17B1 inhibitor FOR-6219 Aug 20, 2019
- Nanotechnology for the treatment of deep endometriosis: a promising option? Jul 20, 2019
- Macrophages identified as cause of endometriotic pain Jul 12, 2019
- Endometriosis: Immune cell discovery could provide relief for women with ‘hidden’ painful disorder Jul 11, 2019
- Small study suggests botulinum toxin may be potential treatment for spasm in women with endometriosis-associated chronic pelvic pain Jul 11, 2019
- Scientists discover key cause of pain for women with endometriosis Jul 11, 2019
- Antibiotic Metronidazole Reduces Size of Endometriosis Lesions, Mouse Study Suggests Jun 4, 2019
- Endometriosis: Are scientists making any headway? May 22, 2019
- Experts: Research Gap Stalls Improvements in Endometriosis Care May 10, 2019
- Antibiotics may treat endometriosis: Targeted treatment reduces number of disease-causing microbes in mice Apr 30, 2019
- Calligonum comosum (Escanbil) extract exerts anti-angiogenic, anti-proliferative and anti-inflammatory effects on endometriotic lesions Apr 26, 2019
- Israeli researchers probe how cannabis can treat endometriosis Apr 24, 2019
- What would an endometriosis blood test mean for patients? Apr 14, 2019
- ‘Groundbreaking’ blood test that can detect endometriosis in 90% of cases could save women years of agonising pain waiting for a diagnosis Apr 2, 2019
- Blood test could detect nine in 10 cases of endometriosis, saving women a long and painful battle Apr 2, 2019
- You Don’t Look Sick: ‘My period pain left me housebound but people don’t believe I’m ill’ – “I am furious that there is still no cure” Mar 24, 2019
- Could a new phone app help change the way we treat endometriosis, one of the most misdiagnosed diseases among women? Mar 21, 2019
- Finding treatment options for endometriosis – “The more I looked into it, the more I realized wow, this is way more than just bad cramps, this is an actual disease” Mar 15, 2019
- Study in Mice Identifies Gal-3 Protein as Driver of Endometriosis, Potential Therapeutic Target Mar 14, 2019
- Endometriosis Must Come ‘Out of the Shadows’: New Review Mar 12, 2019
- Forendo Pharma Successfully Completes Phase 1a Clinical Trial of FOR-6219 for the Treatment of Endometriosis Mar 7, 2019
- Endometriosis is real and periods shouldn’t be painful — despite what my first doctor told me Mar 6, 2019
- Could This Breakthrough Be the First Step Toward an Endometriosis Infertilty Cure? Jan 8, 2019
- Hope for millions suffering endometriosis as scientists work on a ‘cure’ Nov 1, 2018
- New study takes first step toward treating endometriosis Nov 1, 2018
- Study: Gene Therapy Could Lead to new Endometriosis Treatment Aug 6, 2018
- Feinstein Institute discovery promises improved diagnosis and understanding of endometriosis Mar 18, 2018
Research
- Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune cells infiltration in endometriosis Oct 1, 2020
- Endometriosis and the Urinary Tract: From Diagnosis to Surgical Treatment Sep 30, 2020
- Effectiveness of the integration of quercetin, turmeric, and N-acetylcysteine in reducing inflammation and pain associated with endometriosis Sep 14, 2020
- Emodin Reverses the Epithelial-Mesenchymal Transition of Human Endometrial Stromal Cells by Inhibiting ILK/GSK-3β Pathway Sep 10, 2020
- Biological characteristics of endometriotic mesenchymal stem cells isolated from ectopic lesions of patients with endometriosis Aug 8, 2020
- Partners’ perspective in endometriosis research and treatment: A systematic review of qualitative and quantitative evidence Aug 6, 2020
- Long-Term Evolution of Quality of Life and Symptoms Following Surgical Treatment for Endometriosis: Different Trajectories for Which Patients? Jul 31, 2020
- MRI for the diagnosis and staging of deeply infiltrating endometriosis Jul 30, 2020
- The Ethanol Extract of Avocado (Persea americana Mill. (Lauraceae)) Seeds Successfully Induces Implant Regression and Restores Ovarian Dynamic in a Rat Model of Endometriosis Jul 25, 2020
- Epigenetics of Estrogen and Progesterone Receptors in Endometriosis Jul 22, 2020
- Menstrual Effluent Provides a Novel Diagnostic Window on the Pathogenesis of Endometriosis Jul 22, 2020
- Fibrinogen alpha chain (FGA) promotes the migration and invasion of human endometrial stromal cells in endometriosis through FAK/AKT/MMP-2 pathway Jul 22, 2020
- The Role of Ankaferd Blood Stopper and Oxytocin as Potential Therapeutic Agents in Endometriosis: A Rat Model Jul 17, 2020
- Possible involvement of crosstalk between endometrial cells and mast cells in the development of endometriosis via CCL8/CCR1 Jul 8, 2020
- Steroid hormones regulate genome-wide epigenetic programming and gene transcription in human endometrial cells with marked aberrancies in endometriosis Jun 17, 2020
- Research priorities for endometriosis differ among patients, clinicians, and researchers Jun 1, 2020
- The effects of isoliquiritigenin on endometriosis in vivo and in vitro study May 31, 2020
- Atherosclerosis-related biomarkers in women with endometriosis: The effects of dienogest and oral contraceptive therapy Apr 23, 2020
- Activation of ATF3/AP-1 signaling pathway is required for P2X3-induced endometriosis pain Apr 18, 2020
- Expression of Matrix Metalloproteinases and Their Inhibitors in Endometrium: High Levels in Endometriotic Lesions Apr 18, 2020
- Estrogen Receptors and Endometriosis: understanding of the roles of ERα and ERβ in the pathogenesis of endometriosis could pave the way to new therapeutic strategies Apr 17, 2020
- Clotrimazole (CTZ) reduces endometriosis and the estrogen concentration by downregulating aromatase Apr 1, 2020
- Effect of herb-partitioned moxibustion (HPM) on pain and quality of life in women with endometriosis: a protocol for a randomized clinical trial Apr 1, 2020
- Dienogest offers an effective and tolerable alternative or adjunct to surgery and provides many advantages over combined hormonal contraceptives for the treatment of endometriosis Mar 16, 2020
- Accurate Diagnosis of Endometriosis Using Serum MicroRNAs Mar 9, 2020
- A Review of Aberrant DNA Methylation and Epigenetic Agents Targeting DNA Methyltransferase in Endometriosis Feb 27, 2020
- Apoptotic Functions of microRNAs in Pathogenesis, Diagnosis, and Treatment of Endometriosis Feb 11, 2020
- Interventions for endometriosis-related infertility: a systematic review and network meta-analysis Feb 1, 2020
- Adolescent Endometriosis: An Update Dec 5, 2019
- Endometriosis – a decade later – still an enigmatic disease. What is the new in the diagnosis and treatment? Oct 12, 2019
- Ginsenoside Rg3 suppresses endometriosis by inhibiting the viability of human ectopic endometrial stromal cells through the nuclear factor-kappaB signaling pathway Sep 26, 2019
- miR-205-5p inhibits human endometriosis progression by targeting ANGPT2 in endometrial stromal cells Sep 23, 2019
- Endometriosis-associated extracellular vesicles (EVs) contribute to disease pathophysiology by influencing inflammation, angiogenesis, and proliferation within the endometriotic lesion microenvironment Sep 19, 2019
- Suppressive Effects of Ursolic Acid on Human Endometriotic Stromal Cells Survival Sep 17, 2019
- Tokishakuyakusan (TSS), a traditional Japanese medicine (Kampo), represents a possible ideal target of novel therapeutics for endometriosis patients with dysmenorrhea Aug 24, 2019
- Effect of Caffeine and Caffeic Acid Treatment on the Complications Associated with Endometriosis Aug 12, 2019
- Beneficial Effects of Oral Lactobacillus on Pain Severity in Women Suffering from Endometriosis Jul 14, 2019
- Macrophage-derived insulin-like growth factor-1 is a key neurotrophic and nerve-sensitizing factor in pain associated with endometriosis Jul 10, 2019
- Relationship between the amount of ectopic tissue transplanted and the reproductive outcomes in a mouse model of endometriosis Jul 5, 2019
- Elevated heme impairs macrophage phagocytosis in endometriosis Jul 1, 2019
- B lymphocytes inactivation by Ibrutinib limits endometriosis progression in mice Jun 29, 2019
- High-Intensity Focused Ultrasound in the Treatment of Abdominal Wall Endometriosis Jun 27, 2019
- miR-141-3p affects apoptosis and migration of endometrial stromal cells by targeting KLF-12 May 25, 2019
- Peroxisome proliferator-activated receptor-γ coactivator 1α-mediated pathway as a possible therapeutic target in endometriosis May 23, 2019
- LncRNA-H19 regulates cell proliferation and invasion of ectopic endometrium by targeting ITGB3 via modulating miR-124-3p May 11, 2019
- Dienogest or Norethindrone acetate for the treatment of ovarian endometriomas: Can we avoid surgery? May 2, 2019
- Antibiotic therapy with metronidazole reduces endometriosis disease progression in mice: a potential role for gut microbiota Apr 30, 2019
- Silencing of Forkhead Box M1 Reverses Transforming Growth Factor-β1-Induced Invasion and Epithelial-Mesenchymal Transition of Endometriotic Epithelial Cells Apr 30, 2019
- Calligonum comosum (Escanbil) extract exerts anti-angiogenic, anti-proliferative and anti-inflammatory effects on endometriotic lesions Apr 26, 2019
- Hypomethylation of the GSTM1 promoter is associated with ovarian endometriosis: new evidence to support the notion that endometriosis may be an epigenetic disease Apr 16, 2019
- Doxycycline, in combination with progestins such as dienogest, may be an additional therapeutic approach in patients with infiltrative endometriosis with insufficient response to current treatment options Apr 13, 2019
- Downregulation of lncRNA UCA1 is involved in the pathogenesis of ovarian endometriosis and may serve as a promising diagnostic and prognostic biomarker for the disease Apr 11, 2019
- Evaluation of Oxidative Stress and Severity of Endometriosis – “oxidative stress status represents a mechanism which is amenable to treatment or prevention of endometriosis” Apr 10, 2019
- A research on the protein expression of p53, p16, and MDM2 in endometriosis Apr 1, 2019
- Effect of danefukang (DEFK) on symptoms and biomarkers in women with endometriosis Mar 22, 2019
- Synergistic and protective effect of atorvastatin and amygdalin against histopathological and biochemical alterations in Sprague-Dawley rats with experimental endometriosis Mar 19, 2019
- Effects of clarithromycin on inflammatory markers and clinical manifestations in postsurgical follow-up of patients with endometriosis: a double-blinded randomized placebo-controlled clinical trial Mar 19, 2019
- TGR5 agonist INT-777 mitigates inflammatory response in human endometriotic stromal cells: A therapeutic implication for endometriosis Mar 18, 2019
- ATM expression is attenuated by promoter hypermethylation in human ovarian endometriotic stromal cells Mar 14, 2019
- Comparison of long-term use of combined oral contraceptive after gonadotropin-releasing hormone agonist plus add-back therapy versus dienogest to prevent recurrence of ovarian endometrioma after surgery Mar 11, 2019
- Eutopic endometrium from patients with endometriosis modulates the expression of CD36 and SIRP-α in peritoneal macrophages Mar 6, 2019
- Resveratrol reduces the expression of insulin-like growth factor-1 and hepatocyte growth factor in stromal cells of women with endometriosis compared with nonendometriotic women Mar 6, 2019
- Ameliorative effects of luteolin, a therapeutic phytochemical, against endometriosis progression in vitro and in vivo Mar 3, 2019
- A comprehensive review of hormonal and biological therapies for endometriosis: latest developments Feb 27, 2019
- Endometriosis and nuclear receptors Feb 27, 2019
- IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis Feb 21, 2019
- The modulating effects of Resveratrol on the expression of MMP-2 and MMP-9 in endometriosis women: a randomized exploratory trial Feb 19, 2019
- Assessing Research Gaps and Unmet Needs in Endometriosis Feb 18, 2019
- Telocytes enhanced the proliferation, adhesion and motility of endometrial stromal cells as mediated by the ERK pathway in vitro Feb 15, 2019
- Therapeutic Approaches of Resveratrol on Endometriosis via Anti-Inflammatory and Anti-Angiogenic Pathways Feb 13, 2019
- Galectin-3 plays an important role in endometriosis development and is a target to endometriosis treatment Feb 10, 2019
- Evaluation of serum cancer antigen 125, resistin, leptin, homocysteine, and total antioxidant capacity in rat model of endometriosis treated with Curcumin Feb 7, 2019
- Endometriosis treatment with shock waves: A novel approach Feb 5, 2019
- Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis Feb 1, 2019
- Role of a natural integrator based on lipoic acid, palmitoiletanolamide and myrrh in the treatment of chronic pelvic pain and endometriosis Jan 28, 2019
- Cai’s Neiyi Prescription (CNYP) promotes apoptosis and inhibits inflammation in endometrial stromal cells with endometriosis through inhibiting USP10 Nov 23, 2018
- Generation of Progesterone-Responsive Endometrial Stromal Fibroblasts from Human Induced Pluripotent Stem Cells: Role of the WNT/CTNNB1 Pathway Nov 1, 2018
- microRNA Let‐7b: A Novel treatment for endometriosis Jul 31, 2018
- Nobiletin alleviates endometriosis via down-regulating NF-κB activity in endometriosis mouse model Jun 29, 2018
- Clotrimazole is effective for the regression of endometriotic implants in a Wistar rat experimental model of endometriosis Apr 22, 2018
- Daidzein-rich isoflavone aglycones inhibit cell growth and inflammation in endometriosis – “DRIAs might be a potential therapeutic option for management of endometriosis” Apr 18, 2018
Clinical Trials
- Safety and Efficacy Study of MT-2990 in Women With Endometriosis Sep 14, 2020
- Robot-assisted Versus Standard Laparoscopic Approach for the Surgical Treatment of Deep Infiltrating Endometriosis Aug 12, 2020
- Using a Herbal Remedy Extract for the Treatment of Endometriosis Symptoms Jul 30, 2020
- Ovarian Function After Use of Various Hemostatic Techniques During Treatment for Endometrioma Jul 22, 2020
- DLBS1442 for The Treatment of Pain in Patients Suspected Endometriosis Jul 22, 2020
- Endometrioma Treatment and Ovarian Function Jun 30, 2020
- Comparison Elagolix vs Depot Leuprolide Prior to Frozen Embryo Transfers in Patients With Endometriosis Jun 24, 2020
- The Pharmacokinetic(PK)/Pharmacodynamics(PD) Study of SHR7280 Tablets in Premenopausal Subjects With Endometriosis Jun 5, 2020
- Effects of Sulawesi Propolis Extract on Lesion Growth, Apoptotic and Inflammatory Activity of the Rat Endometriosis Tissue May 5, 2020
- A Phase 3 Study to Confirm the Efficacy and Safety of Linzagolix to Treat Endometriosis-associated Pain May 1, 2020
- EndoSearch: Endometriosis Biomarkers Apr 28, 2020
- A Clinical Study to Evaluate the Safety and Efficacy of Elagolix in Participants With Moderate to Severe Endometriosis-Associated Pain Apr 16, 2020
- Evaluating Endometriosis With 16α-(18)F-fluoro-17β-estradiol ([F-18] FES) PET/MRI Apr 15, 2020
- Pre-IVF Treatment With a GnRH Antagonist in Women With Endometriosis – A Prospective Double-blind Placebo-controlled Trial Mar 3, 2020
- A Study to Investigate the Safety, Tolerability, Food Effect, Pharmacokinetics and Pharmacodynamics of FOR-6219 Feb 6, 2020
- Safety and Efficacy Study of MT-2990 in Women With Endometriosis Jan 27, 2020
- Green Tea for Endometriosis Jul 25, 2019
- Treatment With Radiofrequency in Patients With Chronic Pelvic Pain and History of Endometriosis Jul 9, 2019
- Effect of Mediterranean Diet and Physical Activity in Patients With Endometriosis (PHAMEDENDO) Jun 21, 2019
- A Study to Assess the Efficacy and Safety of OBE2109 in Subjects With Endometriosis Associated Pain Jun 10, 2019
- Pomegranate Juice Effect on Oxidative Stress in Infertile Women with PCOS or Endometriosis During IVF Treatment Jun 6, 2019
- Late Phase II Clinical Study of KLH-2109 in Patients With Endometriosis [Completed] Jun 4, 2019
- Clinical Study of NK Cells in the Treatment of Severe Endometriosis May 14, 2019
- Clinical Study to Evaluate Efficacy and Safety of TAK-385 40 mg Compared With Leuprorelin in Patients With Endometriosis Apr 30, 2019
- Once-daily Tablet of V-Endo as Immunotherapy of Endometriosis Apr 16, 2019
- SPIRIT 1: Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain Apr 5, 2019
- Surgical Eradication of Deep Infiltrating Endometriosis of the Vagina Apr 2, 2019
- A Study to Assess the Effectiveness and Safety of Different Doses of ASP1707 Compared to Placebo for Endometriosis Associated Pelvic Pain Mar 29, 2019
- Study to Compare the Oestradiol Suppression, Clinical Efficacy and Safety of Two Formulations of Triptorelin (Triptorelin Pamoate PR 3-month and Triptorelin Acetate PR 1-month) in Subjects With Endometriosis Mar 28, 2019
- Assess Safety and Efficacy of Vilaprisan in Subjects With Endometriosis Mar 19, 2019
- Efficacy of Cryoablation of Abdominal Wall Endometriosis Mar 14, 2019
- Effect of Cannabinoid (THC / CBD 50%) on Hyperalgesia in Patients With Deep Endometriosis Mar 14, 2019
- A Study to Evaluate the Efficacy and Safety of Gefapixant (MK-7264) in Women With Endometriosis-Related Pain (MK-7264-034) Mar 11, 2019
- Randomized Trial Assessing Quinagolide Vaginal Ring for Endometriosis-related Pain (RAQUEL) Mar 5, 2019
- Quinagolide Vaginal Ring on Lesion Reduction Assessed by MRI in Women With Endometriosis/Adenomyosis (QLARITY) Feb 18, 2019
- Assess Safety and Efficacy of Vilaprisan in Subjects With Endometriosis (VILLENDO) Feb 15, 2019
- Effect of Melatonin on Reduction of Pelvic Pain Dec 20, 2018
